Monday, May 27, 2024
HomeNotesPATHOPHYSIOLOGY OF SICKLE CELL ANEMIA

PATHOPHYSIOLOGY OF SICKLE CELL ANEMIA

Published on

Sickle cell anemia

Sickle cell anemia is a severe hemolytic anemia resulting from the inheritance of the sickle hemoglobin (HbS) gene, which causes a defective hemoglobin molecule.

PATHOPHYSIOLOGY

The defective hemoglobin molecule assumes a sickle shape when exposed to low oxygen tension. These long, rigid RBCs become lodged in small vessels and can obstruct blood flow to body tissue. If ischemia or infarction results, the patient may have pain, swelling, and fever. The sickling process takes time; if the erythrocyte is again exposed to adequate amounts of oxygen (eg, when it travels through the pulmonary circulation) before the membrane becomes too rigid, it can revert to a normal shape. For this reason, the “sickling crises” are intermittent.

READ ALSO  TYPES OF NURSING DIAGNOSIS

The HbS gene is inherited, with some people having the sickle cell trait (a carrier, inheriting one abnormal gene) and some having sickle cell disease (inheriting two abnormal genes). Sickle cell disease is found predominantly in people of African descent and less often in people who have descended from the Mediterranean countries, the Middle East, or aboriginal tribes of India.

More like this

SYSTEMIC LUPUS ERYTHEMATOSUS (SLE), A COMMONLY MISDIAGNOSED MEDICAL CONDITION

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that can affect various organ...

WOMAN ARRESTED FOR STEALING LAPTOP AND OTHER ITEMS OF NURSES AND STUDENT NURSES AT HOSPITAL

A young woman has been arrested after she stole some items belonging to nurses...

TWO ROBBERS JAILED 20 YEARS FOR ROBBING STUDENT NURSES

Two robbers Isaac Kwame Bonsu, 19, and Mensah Christian, 18 who were convicted of...

15 STUDENT NURSES AND MIDWIVES OF ATIBIE NTC TO REPEAT OVER POOR PERFORMANCE

About 15 students of the Atibie Nursing and Midwifery Training College in Kwahu have...

Latest articles

MOH ISSUES NEW DIRECTIVES FOR CLEARANCE FROM ENDORSEMENT

The Ministry of Health, Ghana has issued a new directive for clearance form endorsement....

HO TEACHING HOSPITAL: WORLD EMERGENCY MEDICINE DAY 2023

The 27th of May is the day earmarked globally to celebrate Emergency Medicine (EM)....

NURSING ADMISSION FORMS ON SALE FOR THE 2023/2024 ACADEMIC YEAR

The Ministry of Health Ghana has announced to the general public opening of the...