Streptomycin Sulfate (Streptomycin)


Streptomycin Sulfate (Streptomycin) is a common antibiotic used usually against tuberculosis. Streptomycin inhibits CHON synthesis of gram (-) bacteria.

Generic Name

streptomycin sulfate

Drug Class

Antibiotic, anti-tubercular,anti-infective

Specific Action

  • Inhibits CHON synthesis strains of gram negative bacteria, mechanisms of lethal action and fully understood, but functional integrity of cell membrane appears to be disrupted.


  • Infections caused by susceptible strain of mycobacterium tuberculosis.
  • Serious infections caused by susceptible strains of Yersinia Pestis


  • Allergy to aminoglycosides, pregnancy, lactation, Herpes vacinia fungal infection.

Stock Dose

  • 1 gram* / vial
  • *Each vial contains Streptomycin Sulfate USP equivalent to 1 gram Streptomycin.

Nursing Responsibilities

Nursing responsibilities when administering streptomycin

  • Use in route only: give by deep IM injection.
  • Ensure adequate hydration of patient before and during the therapy.
  • Monitor for hearing changes.
  • This drug can only be given by injection.
  • Report hearing changes, dizziness, pain at injection site, rash.